한양대학교 ERICA 산학협력단

> 연구정보 > 연구성과 > HIGHLY CITED PAPERS (HCP)

전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
매월 1회 업데이트

SCIE Article

Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

Author

[Giri, Bhupendra Raj; Kim, Dong Wuk] Kyungpook Natl Univ, FOUR Community Based Intelligent Novel Drug Disco, Vessel Organ Interact Res Ctr VOICE, Coll Pharm,Res Inst Pharmaceut Sci,MRC, Daegu 41566, South Korea; [Kim, Jung Suk; Park, Jong Hyuck; Choi, Han

Corresponding Author Info

Prof. Choi, Han Gon(약학과 최한곤 교수

Professor

E-mail

hangon@hanyang.ac.kr

Document Type

Source

PHARMACEUTICS 2021, 13, 1,

Times Cited

10(2022.2.21.)

External Information

10.3390/pharmaceutics13010111

Abstract

History]
- 7월/8월 2021부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 인용 빈도가 높은 임계값을 기반으로 Pharmacology & Toxicology Science 관련 학술 분야에서 상위 1%에 올랐습니다.

[Abstract]
Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and photo-unstable drug. Several MTX-loaded SASD formulations were developed for spray-drying using water as the solvent, and were investigated for their aqueous solubility and dissolution kinetics. An optimized ternary SASD formulation composed of MTX/ sodium carboxymethyl cellulose (Na-CMC)/sodium lauryl sulfate (SLS) at 3/0.5/0.5 (w/w) had 31.78-fold and 1.88-fold higher solubility and dissolution, respectively, than MTX powder. For SASD, the in vivo pharmacokinetic parameters AUC and C-max were 2.90- and 3.41-fold higher, respectively, than for the MTX powder. Solid-state characterizations by differential scanning calorimetry and X-ray diffraction revealed that MTX exists in its crystalline state within the spray-dried SASD. The MTX-loaded SASD formulation showed few physical changes with photostability testing. Overall, the results indicate that the spray-dried MTX-loaded SASD formulation without organic solvents enhances the solubility and oral bioavailability of MTX without a significant deterioration of its photochemical stability.

Web of Science Categories

Pharmacology & Pharmacy

Funding

National Research Foundation of Korea (NRF) - Korea government [2018R1D1A1B07050598, 2020R1A5A2017323]

Language

English

전체 Excluded 기타

	ENSO Atmospheric Teleconnections and Their Response to Greenhouse Gas Forcing Author(s) : Yeh, Sang-Wook; Cai, Wenju; Min, Seung-Ki; McPhaden, Michael J.; Domme... Source : REVIEWS OF GEOPHYSICS 2018, 56, 185-206 Time Cited : 181 (2022.2.21.)
	Unveiling dual-linkage 3D hexaiminobenzene metal-organic frameworks towards long-lasting advanced reversible Zn-air batteries Author(s) : Shinde, Sambhaji S.; Lee, Chi Ho; Jung, Jin-Young; Wagh, Nayantara K.;... Source : ENERGY & ENVIRONMENTAL SCIENCE 2019, 12, 2, 727-738 Time Cited : 141 (2022.2.21.)
	Unveiling dual-linkage 3D hexaiminobenzene metal-organic frameworks towards long-lasting advanced reversible Zn-air batteries Author(s) : Shinde, Sambhaji S.; Lee, Chi Ho; Jung, Jin-Young; Wagh, Nayantara K.;... Source : ENERGY & ENVIRONMENTAL SCIENCE 2019, 12, 2, 727-738 Time Cited : 141 (2022.2.21.)
	Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs Author(s) : Tran, P; Pyo, YC; Kim, DH; Lee, SE; Kim, JK; Park, JS Source : PHARMACEUTICS 2019, 11, 132 Time Cited : 79 (2022.2.21.)
	Design of highly porous SnO2-CuO nanotubes for enhancing H2S gas sensor performance Author(s) : Park, Kee-Ryung; Cho, Hong-Baek; Lee, Jimin; Song, Yoseb; Kim, Woo-Byo... Source : SENSORS AND ACTUATORS B-CHEMICAL Sensors & Actuators: B. Chemical 302 (2020) 127179 Time Cited : 65 (2022.2.21.)
	Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration Author(s) : Woo, Chang Hee; Kim, Hark Kyun; Jung, Gun Young; Jung, Youn Jae; Lee, ... Source : JOURNAL OF EXTRACELLULAR VESICLES 2020, 9, 1, 1735249 Time Cited : 54 (2022.2.4.)
	Inorganic nanoparticles with enzyme-mimetic activities for biomedical applications Author(s) : Lakshminarayana, G.; Kebaili, Imen; Dong, M. G.; Al-Buriahi, M. S.; Da... Source : COORDINATION CHEMISTRY REVIEWS 403 (2020) 213092 Time Cited : 54 (2022.2.21.)
	Reversible disorder-order transitions in atomic crystal nucleation Author(s) : Jeon, Sungho; Heo, Taeyeong; Hwang, Sang-Yeon; Ciston, Jim; Bustillo, ... Source : Science 2021, 371, 6528, 498 Time Cited : 21 (2022.2.21.)
	Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium Author(s) : [Giri, Bhupendra Raj; Kim, Dong Wuk] Kyungpook Natl Univ, FOUR Communi... Source : PHARMACEUTICS 2021, 13, 1, Time Cited : 10(2022.2.21.)
	Online Control of Preamble Groups With Priority in Massive IoT Networks Author(s) : Liu, Jie (Dept Elect & Elect Engn); Hu Jin (Dept Elect & Elect Engn) ... Source : IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS Volume:39 Issue:3 Pages:700-713 Published:2021 Time Cited : 10 (2022.1.5.)
	Scalable 3-D Carbon Nitride Sponge as an Efficient Metal-Free Bifunctional Oxygen Electrocatalyst for Rechargeable Zn-Air Batteries Author(s) : Shinde, Sambhaji; Lee, Chi-Ho; Sami, Abdul; Kim, Dong-Hyung; Lee, Sang... Source : ACS NANO 2017, 11, 1, 347-357 Time Cited : excluded
	Scalable 3-D Carbon Nitride Sponge as an Efficient Metal-Free Bifunctional Oxygen Electrocatalyst for Rechargeable Zn-Air Batteries Author(s) : Shinde, Sambhaji; Lee, Chi-Ho; Sami, Abdul; Kim, Dong-Hyung; Lee, Sang... Source : ACS NANO 2017, 11, 1, 347-357 Time Cited : excluded
	[Excluded] Estimation of gamma-rays, and fast and the thermal neutrons attenuation characteristics for bismuth tellurite and bismuth boro-tellurite glass systems Author(s) : Lakshminarayana, G; Kebaili, I; Dong, MG; Al-Buriahi, MS; Dahshan, A; ... Source : JOURNAL OF MATERIALS SCIENCE J Mater Sci (2020) 55:5750–5771 Time Cited : Excluded
	[Excluded] Estimation of gamma-rays, and fast and the thermal neutrons attenuation characteristics for bismuth tellurite and bismuth boro-tellurite glass systems Author(s) : Lakshminarayana, G; Kebaili, I; Dong, MG; Al-Buriahi, MS; Dahshan, A; ... Source : JOURNAL OF MATERIALS SCIENCE J Mater Sci (2020) 55:5750–5771 Time Cited : Excluded
	[Excluded]A Real-Time Demand-Response Algorithm for Smart Grids: A Stackelberg Game Approach Author(s) : Yu, M; Hong, SH Source : IEEE TRANSACTIONS ON SMART GRID 2016, 7, 879-888 Time Cited : Excluded
	[Excluded]A Dynamic pricing demand response algorithm for smart grid: Reinforcement learning approach Author(s) : Lu, RZ; Hong, SH; Zhang, XF Source : APPLIED ENERGY 2018,15, 220-230 Time Cited : Excluded
	[Excluded]Incentive-based demand response for smart grid with reinforcement learning and deep neural network Author(s) : Lu, Renzhi; Hong, Hong, Seung Ho; Source : APPLIED ENERGY 2019, 236, 937-949 Time Cited : Excluded
	[Excluded] An Incentive-Based Demand Response (DR) Model Considering Composited DR Resources Author(s) : Yu, Mengmeng; Hong, Seung Ho; Ding, Yuemin; Ye, Xun Source : IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS 2019, 66, 1488-1498 Time Cited : Excluded
	[Excluded] Combined effect of El Nino-Southern Oscillation and Pacific Decadal Oscillation on the East Asian winter monsoon Author(s) : Kim, Ji-Won; Yeh, Sang-Wook; Chang, Eun-Chul Source : CLIMATE DYNAMICS 2014, 42, 3-4, 957-971 Time Cited : Excluded
	[Excluded] Novel visible light active graphitic C3N4-TiO2 composite photocatalyst: Synergistic synthesis, growth Author(s) : Sridharan, Kishore; Jang, Eunyong; Park, Tae Joo Source : APPLIED CATALYSIS B-ENVIRONMENTAL 2013, 142, 718-728 Time Cited : Excluded

1 / 2 /