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Article

Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration

Author

Woo, Chang Hee; Kim, Hark Kyun; Jung, Gun Young; Jung, Youn Jae; Lee, Kyoung Soo; Yun, Ye Eun; Han, Jihoon; Lee, Jeongmi; Kim, Woo Sung; Choi, Ji Suk; Yang, Siyoung; Park, Jae Hyung; Jo, Dong-Gyu; Cho, Yong Woo

Corresponding Author Info

Prof. Cho, Yong Woo (재료화학공학과)

Professor

E-mail

ywcho7@hanyang.ac.kr

Document Type

Source

JOURNAL OF EXTRACELLULAR VESICLES 2020, 9, 1, 1735249

Times Cited

54 (2022.2.4.)

External Information

https://onlinelibrary.wiley.com/doi/10.1080/20013078.2020.1735249

Abstract

[History]
2021년 July/August부로, 이 highly cited paper 의 인용 횟수가 분야와 출판 연도에 대해 인용 빈도가 높은 임계값을 기반으로 Biology & Biochemistry 학술 분야에서 상위 1%에 올랐습니다.

[Abstract]
Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that is the most common joint disease worldwide. Mesenchymal stem cells (MSCs) have been the most extensively explored for the treatment of OA. Recently, it has been demonstrated that MSC-derived extracellular vesicles (EVs) may contribute to the potential mechanisms of MSC-based therapies. In this study, we investigated the therapeutic potential of human adipose-derived stem cells EVs (hASC-EVs) in alleviating OA, along with the mechanism. EVs were isolated from the culture supernatants of hASCs by a multi-filtration system based on the tangential flow filtration (TFF) system. The isolated EVs were characterised using dynamic light scattering (DLS), transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and flow cytometry analysis. The hASC-EVs not only promoted the proliferation and migration of human OA chondrocytes, but also maintained the chondrocyte matrix by increasing type II collagen synthesis and decreasing MMP-1, MMP-3, MMP-13 and ADAMTS-5 &#101xpression in the presence of IL-1 beta in vitro. Intra-articular injection of hASC-EVs significantly attenuated OA progression and protected cartilage from degeneration in both the monosodium iodoacetate (MIA) rat and the surgical destabilisation of the medial meniscus (DMM) mouse models. In addition, administration of hASC-EVs inhibited the infiltration of M1 macrophages into the synovium. Overall results suggest that the hASC-EVs should be considered as a potential therapeutic approach in the treatment of OA.

Web of Science Categories

Cell Biology

Funding

Language

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