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연구성과 > 금주의 우수논문

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SCI-E Article

Fluorescent 2D WS2 Nanosheets Bearing Chemical Affinity Elements for the Recognition of Glycated Hemoglobin
성명 김종호 ()
소속 공학대학 재료화학공학과
캠퍼스
우수선정주 2018년 08월 2째주
Author Yang, Jin-Kyoung (Dept Chem Engn); Lee, Hye-Rim (Dept Chem Engn); Hwang, In-Jun (Dept Chem Engn); Kim, Hye-In (Dept Chem Engn); Yim, DaBin (Dept Chem Engn); 김종호 (Dept Chem Engn) corresponding author;
Corresponding Author Info Kim, JH (reprint author), Hanyang Univ, Dept Chem Engn, Ansan 426791, South Korea.
E-mail 이메일kjh75@hanyang.ac.kr
Document Type Article
Source ADVANCED HEALTHCARE MATERIALS Volume:7 Issue:14 Pages:- Published:2018
Times Cited 0
External Information http://dx.doi.org/10.1002/adhm.201701496
Abstract It is required to exfoliate and functionalize 2D transition metal dichalcogenides (TMDs) in an aqueous solution for biological and medical applications. Herein, the approach for the simultaneous exfoliation and functionalization of 2D WS2 nanosheets using boronic acid-modified poly(vinyl alcohol) (B-PVA) in an aqueous solution is reported, and the B-PVA-functionalized WS2 nanosheets (B-PVA-WS2) are exploited as a fluorescent biosensor for the detection of glycated hemoglobin, HbA1c. The synthetic B-PVA polymer facilitates the exfoliation and functionalization of WS2 nanosheets from the bulk counterpart in the aqueous solution via a pulsed sonication process, resulting in fluorescent B-PVA-WS2 nanohybrids with a specific recognition of HbA1c. The fluorescence of the B-PVA-WS2 is quenched in the presence of HbA1c, whereas PVA-functionalized WS2 (PVA-WS2), not bearing boronic acid as a recognition moiety, shows no fluorescence changes upon the addition of the target. The B-PVA-WS2 is able to selectively detect HbA1c at the concentration as low as 3.3 x 10(-8) m based on its specific fluorescence quenching.
Web of Science Categories Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials
Funding National Research Foundation of Korea - Ministry of Science and ICT [2008-0061891, NRF-2014R1A2A1A11051877, NRF-2017R1A2B2008455]
Language English
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