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연구성과 > 금주의 우수논문

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SCI Article

Effective Suppression of Oxidative Stress on Living Cells in Hydrogel Particles Containing a Physically Immobilized WS2 Radical Scavenger
성명 김종호 ()
소속 공학대학 재료화학공학과
캠퍼스
우수선정주 2019년 06월 2째주
Author Kim, Ji Eun (Dept Bionano Technol); Han, Sang Woo (Dept Bionano Technol); 김진웅 (Dept Bionano Technol) corresponding author; Yim, DaBin (Dept Chem Engn); 김종호 (Dept Chem Engn) corresponding author; Kim, Jin Woong (Dept Chem & Mol Engn);
Corresponding Author Info Kim, JW (reprint author), Hanyang Univ, Dept Bionano Technol, Ansan 15588, South Korea.; Kim, JH (reprint author), Hanyang Univ, Dept Chem Engn, Ansan 15588, South Korea.; Kim, JW (reprint author), Hanyang Univ, Dept Chem & Mol Engn, Ansan 15588, South Ko
E-mail 이메일kjh75@hanyang.ac.kr
Document Type Article
Source ACS APPLIED MATERIALS & INTERFACES Volume:11 Issue:20 Pages:18817-18824 Published:2019
Times Cited 0
External Information http://dx.doi.org/10.1021/acsami.8b22223
Abstract We report a tungsten disulfide (WS2) nanosheet-immobilized hydrogel system that can inhibit oxidative stress on living cells. First, we fabricated a highly stable suspension of WS2 nanosheets as a radical scavenger by enveloping them with the amphiphilic poly(epsilon-caprolactone)-b-poly(ethylene oxide) copolymer (PCL-b-PEO) during in situ liquid exfoliation in aqueous medium. After the PCL-b-PEO-enveloped WS2 nanosheets were embedded in three types of hydrogel systems, including carrageenan gum/locust bean gum bulk hydrogels, physically cross-linked alginate microparticles, and covalently cross-linked PEG hydrogel microparticles, they retained their characteristic optical properties. Intriguingly, the WS2 nanosheet-immobilized hydrogel particles exhibited sustainable radical scavenging performance without any deterioration in the original activity of the WS2 nanosheets, even after repeated use. This implies that the hydrogen atoms dissociated from the chalcogen of the WS2 nanosheets effectively scavenged free radicals through the hydrogel mesh. Because of this unique behavior, the coexistence of the WS2 nanosheets with living cells in the hydrogel matrix improved cell viability up to 40%, which demonstrates that the WS2 nanosheets can suppress oxidative stress on living cells.
Web of Science Categories Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
Funding National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2016R1A2B2016148, 2017R1A2B2008455]
Language English
attached file
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