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전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
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SCIE Article [Excluded] Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors
Author	Ramasamy, Thiruganesh; Ruttala, Hima Bindu; Chitrapriya, Nataraj; Poudal, Bijay Kumar; Choi, Ju Yeon; Kim, Ssang Tae; Youn, Yu Seok; Ku, Sae Kwang; Choi, Han-Gon; Yong, Chul Soon
Corresponding Author Info	Prof. Choi, Han-Gon (최한곤 교수, 약학과)
Professor
E-mail	hangon@hanyang.ac.kr
Document Type
Source	ACTA BIOMATERIALIA 2017, 48, 131-143
Times Cited	Excluded
External Information	http://www.sciencedirect.com/science/article/pii/S1742706116305621
Abstract	- 출판연도: JAN 15 2017 [History] - 2018년 8월 13일 현재 HCP 리스트에서 제외되어 있습니다. - 7월/8월 2017년 부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 Materials Science 관련 학술 분야에서 상위 1%에 올랐습니다. [Abstract] In this study, we report a facile method to construct a bioactive (poly(phenylalanine)-b-poly(t-histidine)-b-poly(ethylene glycol) polypeptide nanoconstruct to co-load doxorubicin (DOX) and quercetin (QUR) (DQ-NV). The smart pH-sensitive nanovehicle was fabricated with precisely tailored drug-to-carrier ratio that resulted in accelerated, sequential drug release. As a result of ratiometric loading, QUR could significantly enhance the cytotoxic potential of DOX, induced marked cell apoptosis; change cell cycle patterns, inhibit the migratory capacity of sensitive and resistant cancer cells. In particular, pro-oxidant QUR from DQ-NV remarkably reduced the GSH/GSSG ratio, indicating high oxidative stress and damage to cellular components. DQ-NV induced tumor shrinkage more effectively than the single drugs in mice carrying subcutaneous SCC-7 xenografts. DQ-NV consistently induced high &#101xpression of caspase-3 and PARP and low &#101xpression of Ki67 and CD31 immunomarkers. In summary, we demonstrate the development of a robust polypeptide-based intracellular nanovehicle for synergistic delivery of DOX/QUR in cancer chemotherapy.
Web of Science Categories	Engineering, Biomedical; Materials Science, Biomaterials
Funding
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